Pharmacokinetics and Indications: Clenbuterol hydrochloride (Clenbuterol) is specifically a selective beta-2 sympathomimetic, primarily affecting only one of the three subsets of betareceptors. Of particular interest is the fact that this drug has little beta-1 stimulating activity. Since beta-1 receptors are closely tied to the cardiac effects of these agents, this allows clenbuterol hydrochloride to reduce reversible airway obstruction (an effect of beta-2 stimulation) with much less cardiovascular side effects compared to non-selective beta agonists. Clinical studies with this drug show it is extremely effective as a bronchodilator, with a low level of user complaints and high patient compliance. Clenbuterol hydrochloride also exhibits an extremely long half-life in the body, which is measured to be approximately 34 hours long. This makes steady blood levels easy to achieve. This of course makes it much easier for the patient to use, and may tie in to its high compliance rate. In animal studies clenbuterol hydrochloride is shown to exhibit anabolic activity ,obviously an attractive trait to a bodybuilder or athlete. This compound is additionally a known thermogenic, with beta-2 agonists like clenbuterol hydrochloride shown to directly stimulate fat cells and accelerate the breakdown of triglycerides to form free fatty acids. Its efficacy in this area makes clenbuterol hydrochloride a very popular fat loss drug producing both benefits, promoting the loss of body fat while imparting increases in strength and muscle mass.
Possible Side Effects: Short-term side effects are those that will subside almost immediately after Clenbuterol is expelled from the body. They also disappear gradually as the drug is discontinued. Short-term side effects that result from Clenbuterol use include Muscle cramps, Increased heart rate, Sweating, Dry mouth, Headache, Lack of sleep, Shaking in the hands, Nervousness/ Anxiety, Difficulty in breathing, Vomiting. The long-term side effects of Clenbuterol use tend to be more serious in nature, and in fact can be downright dangerous. Cardiac hypertrophy (or whats commonly referred to as an enlarged heart) eventually leads to irregular heartbeats known as arrhythmias. Further studies on the effects of Clenbuterol have found that this drug contributes to degeneration of cardiac tissue. Changes in structural dimensions of the heart due to supplemental use of Clenbuterol may cause aortic enlargement after physical activity. Another negative effect of prolonged use of Clenbuterol is the likelihood of developing fragile bones. To avoid these side effects of long-term Clenbuterol use, theres something needed to understand: Youll only experience serious problems if you dont supplement responsibly. The more serious side effects like cardiac hypertrophy, arrhythmias, and uncontrolled weight gain tend to affect users who take too high of doses and supplement for too long a time. In fact, the key to avoiding most side effects of this drug is responsible use. 10 mcg per day is considered safe for first time female users. Women who develop a strong tolerance for Clen can up their doses in the range of 40-60mcg/day with experience. As for male users, 20mcg per day is recommended as a safe starting dose. In case there are no unbearable side effects at beginner level, intermediate male users can increases doses up to 60-80mcg per day. Some pro users comfortably take doses as high as 100-160mcg daily. While results at this level can be significant, keep in mind that the risk of side effects increases at higher doses.
Beginners : 20 - 160 mcg / day
Hobby : 20 - 160 mcg / day
Professionals : 20 - 240 mcg / day
Women : 20 - 120 mcg / day
Use for : 6 - 8 weeks